Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1)
Sachin Puri, Katja Stefan, Sharuk L. Khan, Jens Pahnke, Sven Marcel Stefan, Kapil Juvale
Abstract
had also significant inhibitory power against the multidrug transporter ABCB1 and showed to reverse ABCB1-mediated multidrug resistance (MDR).
Topics & Concepts
ChemistryIndole testTransporterMonocarboxylate transporterBiochemistryPharmacologyStructure–activity relationshipIn vitroStereochemistryGeneMedicineCancer, Hypoxia, and MetabolismChemical Synthesis and AnalysisInflammatory mediators and NSAID effects