Altered Gut Microbiome under Antiretroviral Therapy: Impact of Efavirenz and Zidovudine
Shilpa Ray, Aswathy Narayanan, Christian G. Giske, Ujjwal Neogi, Anders Sönnerborg, Piotr Nowak
Abstract
. Therefore, we observed that ART does not reverse the HIV-induced gut microbiome dysbiosis and might aggravate those microbiota alterations due to the antibacterial effect of certain antiretrovirals (like EFV, ZDV). Our results imply that restructuring the microbiota could be a potential therapeutic target in HIV-1 patients under ART.
Topics & Concepts
EfavirenzBacteroides fragilisZidovudineMicrobiomeBacteroidesDysbiosisMicrobiologyPrevotellaBiologyGut floraVirologyReverse transcriptaseAntibioticsImmunologyHuman immunodeficiency virus (HIV)Antiretroviral therapyViral loadPolymerase chain reactionBacteriaViral diseaseBioinformaticsGeneticsBiochemistryGeneGut microbiota and healthHIV/AIDS Research and InterventionsHIV Research and Treatment