Novel sulfonyl thiazolyl-hydrazone derivatives as EGFR inhibitors: Design, synthesis, biological evaluation and molecular docking studies
Thoraya A. Farghaly, Eman M. H. Abbas, Amerah Alsoliemy, Rehab Sabour, Mohamed R. Shaaban
Topics & Concepts
ChemistryDasatinibIC50CytotoxicityStereochemistryDocking (animal)HydrazoneIn vitroEGFR inhibitorsSulfonylMTT assayCell cultureCombinatorial chemistryBiochemistryEpidermal growth factor receptorReceptorTyrosine kinaseOrganic chemistryAlkylNursingBiologyGeneticsMedicineSynthesis and biological activityQuinazolinone synthesis and applicationsHER2/EGFR in Cancer Research