Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression
María Sabater-Arcis, Ariadna Bargiela, Nerea Moreno, Javier Poyatos‐García, Juan J. Vílchez, Rubén Artero
Abstract
expression, represses excessive autophagy, and downregulates atrophy-related genes of the UPS system. We also detect a significant upregulation of MBNL1 upon MSI2 silencing. Taken together, we propose MSI2 as a new therapeutic target to treat muscle dysfunction in DM1.
Topics & Concepts
Myotonic dystrophyBiologyGene silencingAutophagyRNA splicingMuscle atrophyCell biologymicroRNASkeletal muscleDownregulation and upregulationAlternative splicingGeneticsEndocrinologyGeneExonRNAApoptosisGenetic Neurodegenerative DiseasesMuscle Physiology and DisordersAutophagy in Disease and Therapy