PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1
Liang Wu, Ning Zhao, Zili Zhou, Jinhuang Chen, Shengbo Han, Xudan Zhang, Haijun Bao, Wenzheng Yuan, Xiaogang Shu
Abstract
In general, PLAGL2 promotes the proliferation and migration of GC cells through USP37-mediated deubiquitination of Snail1 protein. This work provided potential therapeutic targets for GC treatment.
Topics & Concepts
Cancer researchCell growthDeubiquitinating enzymeCell biologyIn vivoTranscription factorIn vitroChemistryBiologyUbiquitinGeneBiochemistryBiotechnologyUbiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismRNA modifications and cancer