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Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

Meng Yuan, Linghang Peng, Deli Huang, Amanda L. Gavin, Fangkun Luan, Jenny Tran, Ziqi Feng, Xueyong Zhu, Jeanne Matteson, Ian A. Wilson, David Nemazee

2024Structure10 citationsDOIOpen Access PDF

Topics & Concepts

Phosphodiester bondBiochemistryTrimerChemistryEnzymeActive siteThermostabilityBiologyDimerGeneRNAOrganic chemistryCalcium signaling and nucleotide metabolismCellular transport and secretionSphingolipid Metabolism and Signaling
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4 | Litcius