Eculizumab treatment for renal failure in a pediatric patient with COVID-19
Ruchi Gupta Mahajan, Marissa Lipton, Larisa Broglie, Namrata G. Jain, Natalie Uy
Abstract
While there are increasing reports of acute kidney injury among hospitalized adults with COVID-19, there is still limited information on renal complications associated with COVID-19 in children. The cause of kidney involvement in COVID-19 is likely multifactorial, and appears to involve a complex process, including complement dysregulation and thrombotic microangiopathy. We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with eculizumab.
Topics & Concepts
EculizumabThrombotic microangiopathyMedicineCoronavirus disease 2019 (COVID-19)Complement systemAcute kidney injuryKidneyAtypical hemolytic uremic syndrome2019-20 coronavirus outbreakInternal medicineMicroangiopathyIntensive care medicineImmunologyPathologyAntibodyEndocrinologyDiabetes mellitusDiseaseOutbreakInfectious disease (medical specialty)COVID-19 Clinical Research StudiesCOVID-19 Impact on ReproductionComplement system in diseases