Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-ones under Mild Conditions
Kaixia Sui, Yuting Leng, Yangjie Wu
Abstract
High Resolution Image Download MS PowerPoint Slide A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1- a ]isoquinolin-6(5 H )-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage of this strategy lies in excellent functional group tolerance to generate the corresponding products in good yields under base- and metal-free conditions.
Topics & Concepts
ChemistryBase (topology)CascadeReaction conditionsCombinatorial chemistryFunctional groupOrganic chemistryMathematicsCatalysisChromatographyMathematical analysisPolymerCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Biological Evaluation