Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors
Shuangshuang Xie, Changxing Qi, Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Yin Xu, Weiguang Sun, Yuan Zhou, Yonghui Zhang
Abstract
Cyclooxygenase-2 (COX-2) is a significant therapeutic target of chronic inflammatory diseases.
Topics & Concepts
ChemistryCyclooxygenasePharmacologyBiochemistryEnzymeMedicineNatural Compound Pharmacology StudiesSynthesis of Organic CompoundsBioactive Compounds and Antitumor Agents