A computer-simulated mechanism of familial Alzheimer’s disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase
Budheswar Dehury, Arun Kumar Somavarapu, Kasper P. Kepp
Topics & Concepts
Mechanism (biology)Substrate (aquarium)Dynamics (music)MutationMolecular dynamicsBiophysicsChemistryNeuroscienceBiologyGeneticsCell biologyPsychologyPhysicsGeneEcologyComputational chemistryQuantum mechanicsPedagogyProtein Structure and DynamicsComputational Drug Discovery MethodsAlzheimer's disease research and treatments