Detection of lineage-reprogramming efficiency of tumor cells in a 3D-printed liver-on-a-chip model
Zuyan Lu, Xiangwan Miao, Qianqian Song, Huifen Ding, Shiny Amala Priya Rajan, Aleksander Skardal, Konstantinos I. Votanopoulos, Kerong Dai, Weixin Zhao, Baisong Lu, Anthony Atala
Abstract
Our findings demonstrate that reprogramming could be a promising method to produce hepatocytes and treat TNBC liver metastasis. And the LOC model could intimate the 3D liver microenvironment and assess the behavior of the reprogrammed TNBC cells.
Topics & Concepts
ReprogrammingCancer researchBiologyCell biologyMetastasisCellChemistryCancerGenetics3D Printing in Biomedical ResearchPluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics