Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds
Yebin Wu, Youzhi Wu, Jian Wu, Dan Xu, Hui Jiang, Wen-wu Chang, Chang-you Ma
Abstract
The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chemistry, especially for substrates with bulky secondary alkyl groups. Described herein is a copper-catalyzed coupling reaction of pyridone derivatives with tosylhydrazones.
Topics & Concepts
ChemistryRegioselectivityHydrazoneAlkylationAlkylCatalysisCopperCoupling reactionOrganic chemistryCombinatorial chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions