P-selectin–deficient mice to study pathophysiology of sickle cell disease
Margaret F. Bennewitz, Egemen Tütüncüoğlu, Shweta Gudapati, Tomasz Brzóska, Simon C. Watkins, Satdarshan P. Monga, Tirthadipa Pradhan‐Sundd, Prithu Sundd
Abstract
Key Points P-selectin–deficient SCD mice are protected from lung vaso-occlusion. P-selectin–deficient SCD mice will be useful in assessing the benefits of anti–P-selectin therapy in diverse complications of SCD.
Topics & Concepts
PathophysiologyMedicineP-selectinAcute chest syndromeSelectinDiseaseE-selectinL-selectinImmunologySickle cell anemiaCellInternal medicineInflammationCell adhesion moleculeBiologyCell adhesionGeneticsPlateletPlatelet activationHemoglobinopathies and Related DisordersMyeloproliferative Neoplasms: Diagnosis and TreatmentBlood groups and transfusion