Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation
Yaling Wang, Jingwen Chen, Xueying Huang, Bangguo Wu, Peng Dai, Feng Zhang, Jinsong Li, Lingbo Wang
Topics & Concepts
BiologySomatic cellGermlineGeneticsGeneGerm cellZona pellucidaMale infertilityGene knockoutPhenotypeSpermZygoteInfertilityOocyteEmbryoEmbryogenesisPregnancyCRISPR and Genetic EngineeringInsect symbiosis and bacterial influencesEvolution and Genetic Dynamics