[5]-Helistatins: Tubulin-Binding Helicenes with Antimitotic Activity
James L. Rushworth, Aditya R. Thawani, Elena Fajardo-Ruiz, Joyce C. M. Meiring, Constanze Heise, Andrew J. P. White, Anna Akhmanova, Jochen R. Brandt, Oliver Thorn‐Seshold, Matthew J. Fuchter
Abstract
-stilbenes-themselves common drug and natural product scaffolds. Overall, this study further supports future opportunities for helicenes for a range of chemical biological applications.
Topics & Concepts
Antimitotic AgentTubulinChemistryPharmacologyMedicineMicrotubuleBiologyCell biologySynthesis and Properties of Aromatic CompoundsAxial and Atropisomeric Chirality SynthesisOrganic Chemistry Cycloaddition Reactions