A Novel lncRNA, AK130181, Contributes to HIV-1 Latency by Regulating Viral Promoter-Driven Gene Expression in Primary CD4+ T Cells
Haiyu Li, Xiangbo Chi, Rong Li, Jing Ouyang, Yaokai Chen
Abstract
T cells from HIV-1-infected individuals treated with highly active antiretroviral therapy significantly increased viral reactivation upon T cell activation in vivo. We provide new insights and a better understanding of lncRNAs that play a role in HIV-1 latency, and suggest that silencing AK130181 expression to activate HIV-1 latently infected cells may be a potential therapeutic target for HIV-infected individuals.
Topics & Concepts
Jurkat cellsBiologyGene silencingVirus latencyGeneVirologyLong non-coding RNAGene expressionRNA interferenceGeneticsViral replicationRNAT cellVirusImmune systemCancer-related molecular mechanisms researchImmune Cell Function and Interaction