Burden of respiratory viral infection in persons with human immunodeficiency virus
Subhashini A. Sellers, Kenton Dover, Aubrey Bailey, Avery Cheves, Anthony B. Eason, Elena B. Popowitch, Melissa B. Miller, David A. Wohl, Dirk P. Dittmer, William A. Fischer
Abstract
This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real-time reverse transcription polymerase chain reaction and primer-independent next-generation sequencing (NGS). Of 82 subjects, respiratory viruses were the most common pathogen identified in 27 (33%), followed by fungus and bacteria in 8 (10%) and 4 (5%) subjects, respectively. Among subjects with RVI, 11 (41%) required ICU admission and 16 (59%) required mechanical ventilation. The proportion of respiratory viruses identified, and the associated complicated hospital course highlights the significant role that RVIs play in the lung health of PLH.