Podocyte injury at young age causes premature senescence and worsens glomerular aging
Beatriz Maria Veloso Pereira, Yuting Zeng, Joseph C. Maggiore, Robert Allen Schweickart, Diana G. Eng, Natalya Kaverina, Sierra R. McKinzie, Anthony Chang, Carol Loretz, Karina Thieme, Neil A. Hukriede, Jeffrey W. Pippin, Oliver Wessely, Stuart J. Shankland
Abstract
Glomerular function is decreased by aging. However, little is known about the molecular mechanisms involved in age-related glomerular changes and which factors could contribute to a worse glomerular aging process. Here, we reported that podocyte injury in young mice and culture podocytes induced senescence, a marker of aging, and accelerates glomerular aging when compared with healthy aging mice.
Topics & Concepts
PodocyteSenescenceGlomerulosclerosisNephrinInternal medicineEndocrinologyFocal segmental glomerulosclerosisMedicineBiologyKidneyGlomerulonephritisProteinuriaRenal Diseases and GlomerulopathiesGenetic and Kidney Cyst DiseasesChronic Kidney Disease and Diabetes