The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication
Benjamin E. Nilsson-Payant, Skyler Uhl, Adrien Grimont, Ashley S. Doane, Phillip Cohen, Roosheel S. Patel, Christina A. Higgins, Joshua A. Acklin, Yaron Bram, Vasuretha Chandar, Daniel Blanco-Melo, Maryline Panis, Jean K. Lim, Olivier Elemento, Robert E. Schwartz, Brad R. Rosenberg, Rohit Chandwani, Benjamin R. tenOever
Abstract
The COVID-19 pandemic has caused significant mortality and morbidity around the world. Although effective vaccines have been developed, large parts of the world remain unvaccinated while new SARS-CoV-2 variants keep emerging. Furthermore, despite extensive efforts and large-scale drug screenings, no fully effective antiviral treatment options have been discovered yet. Therefore, it is of the utmost importance to gain a better understanding of essential factors driving SARS-CoV-2 replication to be able to develop novel approaches to target SARS-CoV-2 biology.