MET-targeted NIR II luminescence diagnosis and up-conversion guided photodynamic therapy for triple-negative breast cancer based on a lanthanide nanoprobe
Yanxing Wang, Miao Feng, Bi Lin, Xiangrong Peng, Zhan Wang, Ruichan Lv
Abstract
when intravenously injected due to the positive targeted imaging effects of the cMBP peptide toward MET and negative targeted imaging effects relating to enhanced permeability and retention (EPR ). This specially designed ZUPEA probe with integrated diagnosis and treatment functionality provides new ideas and prospects for the use of rare-earth nanoparticles in the clinical treatment of tumors.
Topics & Concepts
NanoprobePhotodynamic therapyPhoton upconversionTriple-negative breast cancerLanthanideLuminescenceBreast cancerMaterials scienceMedicineCancer researchCancerNanoparticleNanotechnologyOptoelectronicsChemistryInternal medicineIonOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence Properties of Advanced Materials