Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-<i>a</i>]isoquinolines
Dongmei Chi, Hongbo Qi, Leming Wang, Shufeng Chen
Abstract
A palladium-catalyzed enantioselective intramolecular Heck cyclization/carbonylation reaction has been developed, which utilizes formates as the source of CO to enantioselectively synthesize ester-substituted indolo[2,1- a ]isoquinolines.
Topics & Concepts
ArylEnantioselective synthesisCatalysisCascadeCarbonylationChemistryCombinatorial chemistryOrganic chemistryCarbon monoxideAlkylChromatographyCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions