A Biopharmaceutical Perspective on Higher-Order Structure and Thermal Stability of mRNA Vaccines
Marek Kloczewiak, Jessica M. Banks, Lin Jin, Mark L. Brader
Abstract
2021, 120, 2766]. We extend those findings by considering the effect of encapsulation on mRNA thermal unfolding with the observation that encapsulation in LNPs increases mRNA unfolding temperatures.
Topics & Concepts
BiopharmaceuticalMessenger RNAChemistryComputational biologyBiologyBiochemistryGeneGeneticsRNA Interference and Gene DeliveryRNA and protein synthesis mechanismsBacteriophages and microbial interactions