Light-triggered toll-like receptor activation in a nanoscale metal–organic framework for synergistic PDT and cancer immunotherapy
Yibin Mao, Langston Tillman, Xiaomin Jiang, Wangqing Bian, Chaoyu Wang, Tobias Fromme, Ralph R. Weichselbaum, Wenbin Lin
Abstract
a ROS-sensitive linker for combined PDT and immunotherapy. Upon light irradiation, the DBP photosensitizer within the MOF generates both singlet oxygen and hydroxyl radicals, enabling simultaneous induction of PDT and triggered release of R848. This dual-function platform effectively induces cancer cell death and suppresses tumour growth in colon cancer models, demonstrating its potential as an on-demand and synergistic cancer immunotherapy strategy.
Topics & Concepts
ImmunotherapyInnate immune systemImmune systemCancer immunotherapyToll-like receptorCancerCancer researchNanoscopic scaleMedicineNanotechnologyChemistryMaterials scienceImmunologyInternal medicineNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and ApplicationsImmune cells in cancer