Enantioselective reaction of <i>N</i>-cyano imines: decarboxylative Mannich-type reaction with malonic acid half thioesters
Yusuke Oyamada, Kazuto Inaba, Takahiro Sasamori, Shuichi Nakamura
Abstract
The enantioselective Mannich-type reaction between N -cyano imines with malonic acid half thioesters (MAHTs) was accomplished by using a quinidine-derived chiral squaramide catalyst.
Topics & Concepts
Enantioselective synthesisMalonic acidChemistryCyanamideFunctional groupMannich reactionMedicinal chemistryOrganic chemistryCatalysisPolymerSynthesis and Catalytic ReactionsAsymmetric Synthesis and CatalysisSynthesis of β-Lactam Compounds