Bioinspired Diversification Approach Toward the Total Synthesis of Lycodine-Type Alkaloids
Hannah M. S. Haley, Stefan E. Payer, Sven M. Papidocha, Simon Clemens, Jonathan Nyenhuis, Richmond Sarpong
Abstract
-desmethyl-β-obscurine. Key steps in the syntheses include oxidative C-C bond cleavage of a piperidine ring in the core structure of the obscurine intermediate and site-selective C-H borylation of a pyridine nucleus to enable cross-coupling reactions.
Topics & Concepts
ChemistryTotal synthesisBorylationPiperidineStereochemistryCleavage (geology)PyridineRing (chemistry)Structural motifCombinatorial chemistryBond cleavageOrganic chemistryCatalysisAlkylBiochemistryGeotechnical engineeringEngineeringArylFracture (geology)Cholinesterase and Neurodegenerative DiseasesChemical synthesis and alkaloidsNicotinic Acetylcholine Receptors Study