Stereodivergent conjugate reduction of α-substituted α,β-unsaturated <i>N</i>-sulfinyl ketimines: flexible access to challenging acyclic β,β-disubstituted enesulfinamides
Nuermaimaiti Yisimayili, Tao Liu, Teng-Zhao Xiong, Chong‐Dao Lu
Abstract
Stereodivergent 1,4-reduction to provide flexible access to the challenging acyclic enesulfinamides featuring two electronically and sterically similar β-substituents.
Topics & Concepts
ChemistryConjugateSteric effectsReduction (mathematics)Combinatorial chemistryStereochemistryMedicinal chemistryMathematicsMathematical analysisGeometrySulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms