Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway
Ruili Li, Sha-Jie Dang, Minna Yao, Chao Zhao, Wei Zhang, Jia Cui, Jingwen Wang, Aidong Wen
Abstract
-receptor-dependent JNK signaling pathway in spinal astrocytes, and osthole could be considered a potential pharmacotherapy to alleviate neuropathic pain.
Topics & Concepts
Neuropathic painMedicinePharmacologyAstrocyteCREBHyperalgesiaAnalgesicAllodyniaNeuralgiaIn vivoInflammationChronic painNociceptionReceptorImmunologyCentral nervous systemChemistryInternal medicineBiologyPhysical therapyBiochemistryTranscription factorGeneBiotechnologyPain Mechanisms and TreatmentsPharmacological Effects of Natural CompoundsNeuropeptides and Animal Physiology