Catalase-like pleated niobium carbide MXene loaded with polythiophene for oxygenated sonodynamic therapy in solid tumor
E Pang, Baoling Li, Chuanling Zhou, Shaojing Zhao, Yu Tang, Qiuxia Tan, Chaoyi Yao, Benhua Wang, Kai Han, Xiangzhi Song, Zhe-Yu Hu, Quchang Ouyang, Shiguang Jin, Minhuan Lan
Abstract
levels and reduced tumor cell activity. Moreover, the decomposed NSs led to the release of the sonosensitizer PT2 that can efficiently generate both singlet oxygen and superoxide anions under ultrasound irradiation. These events led to the inhibition of DNA replication of tumor cells, causing tumor cell death, allowing for enhanced SDT efficacy.
Topics & Concepts
PolythiopheneMaterials scienceSonodynamic therapyCarbideNiobiumNiobium carbideCatalaseChemical engineeringNanotechnologyMetallurgyComposite materialPolymerChemistryOrganic chemistryConductive polymerPhotodynamic therapyAntioxidantEngineeringNanoplatforms for cancer theranosticsMXene and MAX Phase MaterialsAdvanced Photocatalysis Techniques