Pancreatic and duodenal homeobox-1 (PDX1) contributes to β-cell mass expansion and proliferation induced by Akt/PKB pathway
Mark Anthony Jara, João Pedro Werneck‐de‐Castro, Camila Lubaczeuski, James D. Johnson, Ernesto Bernal‐Mizrachi
Abstract
mice. In conclusion, PDX1 contributes to β-cell mass expansion and glucose metabolism induced by activation of Akt signaling.
Topics & Concepts
PDX1Glucose homeostasisProtein kinase BEndocrinologyInternal medicineBiologyHomeostasisCell biologyCell growthmTORC1PI3K/AKT/mTOR pathwayChemistryInsulinSignal transductionInsulin resistanceMedicineBiochemistryIsletPancreatic function and diabetesMetabolism, Diabetes, and CancerDiabetes Management and Research