Palladium-Catalyzed Remote Hydro-Oxygenation of Internal Alkenes: An Efficient Access to Primary Alcohols
Xiang Li, Xintuo Yang, Pinhong Chen, Guosheng Liu
Abstract
As a general method for the synthesis of alcohols, the direct oxygenation of alkenes is difficult to afford linear alcohols. Herein, we communicate the remote hydro-oxygenation of alkenes under palladium catalysis, in which both terminal and internal alkenes are suitable to yield the corresponding linear alcohols efficiently. A compatible SelectFluor/silane redox system plays an essential role for the excellent chemo- and regioselectivities. The reaction features a broad substrate scope and excellent functional group compatibility.
Topics & Concepts
ChemistryCatalysisPalladiumSelectfluorAlkeneCombinatorial chemistryOxygenationSilanePrimary (astronomy)Organic chemistryFunctional groupAstronomyPolymerEcologyPhysicsBiologyCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions