Assessment of potential SARS-CoV-2 virus integration into human genome reveals no significant impact on RT-qPCR COVID-19 testing
Erica M. Briggs, William Ward, S. I. Rey, Dylan Law, Katharine J. Nelson, Michael Bois, Nili Ostrov, Henry H. Lee, Jon M. Laurent, Paolo Mita
Abstract
With advancements in stem cell technology, in vitro models using iPSC (induced pluripotent stem cells)-derived cardiomyocytes (iPSC-CM) and engineered heart tissues (EHT) can serve as powerful tools for disease modeling and drug screening. ...Fluorescent reporters of cardiac electrophysiology provide valuable information on heart cell and tissue function. However, motion artifacts caused by cardiac muscle contraction interfere with accurate measurement of fluorescence signals. Although drugs ...
Topics & Concepts
Induced pluripotent stem cellBiologyComputational biologyDrug discoveryCoronavirus disease 2019 (COVID-19)Stem cellCellGenomeIn vitroVirologyCardiac electrophysiologyCell biologyNeuroscienceBioinformaticsElectrophysiologyEmbryonic stem cellMedicineDiseaseInfectious disease (medical specialty)GeneticsPathologyGeneSARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingCRISPR and Genetic Engineering