Ikoamide, an Antimalarial Lipopeptide from an <i>Okeania</i> sp. Marine Cyanobacterium
Keitaro Iwasaki, Arihiro Iwasaki, Shimpei Sumimoto, Teruhiko Matsubara, Toshinori Sato, Tomoyoshi Nozaki, Yumiko Saito‐Nakano, Kiyotake Suenaga
Abstract
An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.
Topics & Concepts
LipopeptideDerivatizationCyanobacteriaCytotoxicityAbsolute configurationPlasmodium falciparumStereochemistryIC50ChemistryChiral column chromatographyHigh-performance liquid chromatographyPharmacognosyBiological activityBiologyBacteriaChromatographyBiochemistryIn vitroMalariaGeneticsImmunologyMarine Sponges and Natural ProductsMalaria Research and ControlMicrobial Natural Products and Biosynthesis