The landscape of <i>CD28, CD80, CD86, CTLA4</i>, and <i>ICOS</i> DNA methylation in head and neck squamous cell carcinomas
Luka de Vos, Ingela Grünwald, Emma Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Abstract
expression levels are epigenetically co-regulated by DNA methylation. This study provides rationale to test their DNA methylation as potential biomarker for prediction of response to CTLA-4 immune checkpoint inhibitors.
Topics & Concepts
BiologyDNA methylationCpG siteMethylationCD80Head and neck squamous-cell carcinomaEpigeneticsCancer researchCD86CD28ImmunotherapyImmune systemT cellMolecular biologyGeneImmunologyCancerCytotoxic T cellGene expressionGeneticsHead and neck cancerCD40In vitroEpigenetics and DNA MethylationCancer Immunotherapy and BiomarkersImmune cells in cancer