Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons
Barış Genç, Javier H. Jara, Santana S. Sanchez, Amiko K. B. Lagrimas, Öge Gözütok, Nuran Koçak, Yongling Zhu, P. Hande Özdi̇nler
Topics & Concepts
Amyotrophic lateral sclerosisNeurodegenerationMotor neuronBiologyNeuroscienceSOD1Hereditary spastic paraplegiaUpper motor neuronDeubiquitinating enzymeGenetic enhancementUbiquitinSpinal cordCell biologyGeneDiseasePathologyMedicineGeneticsPhenotypeAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchNerve injury and regeneration