Copper-catalyzed radical ring-opening halogenation with HX
Shuai Liu, Ming Bai, Peng‐Fei Xu, Qing-Xin Sun, Xin‐Hua Duan, Li‐Na Guo
Abstract
An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields.
Topics & Concepts
HalogenationAlkylChemistryRing (chemistry)CatalysisCopperMedicinal chemistryCombinatorial chemistryOrganic chemistryOxidative Organic Chemistry ReactionsVanadium and Halogenation ChemistryCatalytic C–H Functionalization Methods