Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor
Jessica A. Breznik, Jennifer Jury, Elena F. Verdú, Deborah M. Sloboda, Dawn M. E. Bowdish
2023American Journal of Physiology-Gastrointestinal and Liver Physiology16 citationsDOIOpen Access PDF
Abstract
We found that diet-induced obesity in female mice has tissue- and time-dependent effects on intestinal paracellular permeability as well as monocyte-derived and tissue-resident macrophage numbers, surface marker phenotype, and intracellular production of the cytokines IL-10 and TNF. These changes were not mediated by TNF.
Topics & Concepts
Proinflammatory cytokineTumor necrosis factor alphaMonocyteIleumInflammationBiologyMacrophageAdipose tissueEndocrinologyInternal medicineAdipose tissue macrophagesEx vivoImmunologyIn vivoMedicineIn vitroBiochemistryBiotechnologyWhite adipose tissueAdipokines, Inflammation, and Metabolic DiseasesImmune cells in cancerDietary Effects on Health