Design, synthesis, and cytotoxicity of ibuprofen-appended benzoxazole analogues against human breast adenocarcinoma
Vishnu Thumma, Veerabhadraiah Mallikanti, Raghavender Matta, Ravinder Dharavath, Jalapathi Pochampally
Abstract
. The molecular docking study against ERα unveiled their best docking scores and binding interactions in agreement to experimental results. Pharmacokinetics prediction envisaged their drug-like properties suitable for therapeutic applications.
Topics & Concepts
BenzoxazoleCytotoxicityIbuprofenAdenocarcinomaHuman breastChemistryCancer researchPharmacologyMedicineInternal medicineBreast cancerIn vitroBiochemistryOrganic chemistryCancerSynthesis and biological activityClick Chemistry and ApplicationsComputational Drug Discovery Methods