Asymmetric synthesis of 3-benzyl and allyl isoindolinones by Pd-catalyzed dicarbofunctionalization of 1,1-disubstituted enamides
Wenyi Huang, Mohini Shrestha, Chenchen Wang, Fang Ke, Yaxin Teng, Jingping Qü, Yifeng Chen
Abstract
The Pd-catalyzed enantioselective Heck/Suzuki reaction of 1,1-disubstituted enamides with aryl/vinyl boronic acids has been developed to access 3-benzyl/allyl substituted isoindolinones bearing a tetrasubstituted stereogenic carbon center.
Topics & Concepts
ChemistryStereocenterEnantioselective synthesisCatalysisArylCombinatorial chemistryOrganic chemistryMedicinal chemistryAlkylSynthesis and pharmacology of benzodiazepine derivativesSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods