Effect of Convolvulus arvensis Ethanolic Extract on Testosterone-induced Alopecia in Mice
Mena E. Naji, Fouad Kadhim Gatea, Kholod A. Ali, Ahmed R. A. Raghif
Abstract
Background and Objective: Androgenetic alopecia is an age-related disease. It’s the most prevalent type of non-scarring progressive hair loss, affecting men and women. Here, Convolvulus arvensis ethanolic extract is investigated for its growth-promoting effects in albino mice with testosterone-induced hair loss. Material and Method: 50 adult male albino mice (2-3 month) divided into 5 group 10 mice in each group (I) intact negative control (II) Testosterone gel 1% only (induction group) (III) Testosterone gel 1% + finasteride solution 2% (standard group) (IV) testosterone gel 1% + Convolvulus arvensis cream 3% (extract group) (V) testosterone gel 1% + glycerine cream 15% (vehicle group) testosterone gel 1% was applied topically to the back of the mice to all group except negative control group (I) for 21 days to induce hair loss hair growth promoting effect evaluated by visual observation, histopathological study of follicular density and anagen/telogen ratio and testosterone, dihydrotestosterone serum level. Result: animals in extract group showed less hair loss as compared to those treated with induction and vehicle groups that possess A patch of hair loss, Convolvulus arvensis ethanolic extract increase follicular density and anagen/telogen ratio significantly compared to induction group, these result suggest that extract promotes hair growth and prevent hair loss by inducing the anagen phase in resting hair follicles and might therefore be a potential hair growth-promoting agent.