Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol
Layara Akemi Abiko, Raphael Dias Teixeira, Sylvain Engilberge, Anne Grahl, Tobias Mühlethaler, Timothy Sharpe, Stephan Grzesiek
Topics & Concepts
ChemistryAllosteric regulationIsothermal titration calorimetryCholesterolReceptorBiophysicsStereochemistryCrystallographyBiochemistryBiologyReceptor Mechanisms and SignalingLipid Membrane Structure and BehaviorNeuropeptides and Animal Physiology