Copper catalyzed dearomatization by Michael-type addition of indolyl ynones: divergent synthesis of functionalized spiroindoles and cyclopenta[<i>c</i>]quinolin-3-ones
Guang-Xin Ru, Meng Zhang, Tingting Zhang, Xiao‐Lei Jiang, Guangqin Gao, Xiu-Hong Zhu, Shun Wang, Cai-Ling Fan, Xiao Li, Wen‐Bo Shen
Abstract
Described herein is a copper-catalyzed multifunctionalization of indolyl ynones, allowing the synthesis of dihalogen-substituted spiroindoles. This Cu catalysis is also applicable to the synthesis of cyclopenta[ c ]quinolin-3-ones via decarbonylation.
Topics & Concepts
ChemistryCatalysisCopperDecarbonylationMichael reactionOrganic chemistryMedicinal chemistryCombinatorial chemistryCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesAsymmetric Synthesis and Catalysis