A codelivery system loaded with PDL1-siRNA and sorafenib enhances the therapeutic effect of sorafenib on hepatocellular carcinoma via TAT-poly-SS-lysine modified chitosan
Yanan Chen, Zhonghao Jiang, Zhuo Yan, Jierong Liu, Yilin Lai, Li Li, Lin Xiao, Jiantao Lin
Topics & Concepts
SorafenibHepatocellular carcinomaApoptosisCancer researchDownregulation and upregulationIn vivoChemistryTransfectionPharmacologyMedicineBiologyBiochemistryGeneBiotechnologyRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryProtein Degradation and Inhibitors