Synthesis of Sulfonamide Tethered (Hetero)aryl ethylidenes as Potential Inhibitors of P2X Receptors: A Promising Way for the Treatment of Pain and Inflammation
Abid Mahmood, Rubina Munir, Muhammad Zia‐ur‐Rehman, Noman Javid, Syed Jawad Ali Shah, Lubna Noreen, Tayyaba Allamgir Sindhu, Jamshed Iqbal
Abstract
-P2X2 receptor that were comparable to the positive control suramin and pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS).
Topics & Concepts
ReceptorPPADSChemistrySuraminPharmacologyAgonistP2 receptorPotencyBiochemistryIn vitroMedicineAdenosine and Purinergic SignalingSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions