TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling
Peng Peng, Hongtao Zhu, Dan Liu, Zirong Chen, Xiaolin Zhang, Zhongyin Guo, Minhai Dong, Li‐Jun Wan, Po Zhang, Guohao Liu, Suojun Zhang, Fangyong Dong, Feng Hu, Fangling Cheng, Shijun Huang, Dongsheng Guo, Bin Zhang, Xingjiang Yu, Feng Wan
Abstract
TAM-derived TGFBI promotes GSC-driven tumor growth through integrin αvβ5-Src-Stat3 signaling. High serum or CSF TGFBI may serve as a potential diagnostic and prognostic bio-index for GBMs.
Topics & Concepts
TGFBIGliomaCancer researchU87Tumor progressionSTAT3Tumor microenvironmentIntegrinBiologyStem cellSignal transductionMedicineCellTransforming growth factorCancerInternal medicineCell biologyTumor cellsGeneticsImmune cells in cancerGlioma Diagnosis and TreatmentTGF-β signaling in diseases