Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
Anastasia A. Beloglazkina, N. V. Zyk, Alexander G. Majouga, Елена К. Белоглазкина
Abstract
This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53- Mouse double minute 2 homolog (MDM2) protein-protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics.
Topics & Concepts
Mdm2Small moleculeP53 proteinProtein–protein interactionCytotoxicityChemistryMoleculeComputational biologyCell biologyBiochemistryBiophysicsBiologyIn vitroApoptosisOrganic chemistryCancer-related Molecular PathwaysMicrotubule and mitosis dynamicsClick Chemistry and Applications