A Practical Method for the Synthesis of Donor‐Acceptor Cyclobutanes by Cu(OAc) <sub>2</sub> or FeCl <sub>3</sub> Catalyzed [2+2] Cycloaddition
Hui Luo, Jun Yan, Zuliang Chen, Yingjing Wei, Bin Chen, Yu Liu
Abstract
Abstract Cu(OAc) 2 or FeCl 3 catalyzed [2+2] cycloaddition reaction between terminal alkenes and unpurified dialkyl methylidenemalonates was revealed. This new method represents a scalable and convenient approach for the transformation of alkenes into donor‐acceptor cyclobutanes.
Topics & Concepts
CyclobutanesCycloadditionCatalysisChemistryAcceptorTransformation (genetics)Medicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryPhysicsGeneBiochemistryCondensed matter physicsCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions