DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer
Shaoqiang Guo, Miaomiao Miao, Yufeng Wu, Dongyue Pan, Qinyan Wu, Zhanfang Kang, Jianwen Zeng, Guoping Zhong, Chengfei Liu, Junjian Wang
Topics & Concepts
Prostate cancerDihydroorotate dehydrogenaseCancer researchApoptosisCancerBiologyPyrimidine metabolismProstateAbiraterone acetateTestosterone (patch)PharmacologyInternal medicineMedicineAndrogen deprivation therapyEnzymeBiochemistryPurineBiochemical and Molecular ResearchProstate Cancer Treatment and ResearchCancer, Hypoxia, and Metabolism