Theaflavin-regulated Imd condensates control Drosophila intestinal homeostasis and aging
Qingshuang Cai, Shanming Ji, Mengwan Li, Sen Zheng, Xiuhong Zhou, Huimin Guo, Siyu Deng, Junyan Zhu, Daxiang Li, Zhongwen Xie
Abstract
. Mechanistically, theaflavins regulate the condensate assembly of Imd to negatively govern the overactivation of Imd signals in fruit fly intestines. In addition, theaflavins prevent DSS-induced colitis in mice, suggesting theaflavins play a role in modulating intestinal integrity. Overall, our study reveals a molecular mechanism by which theaflavins regulate gut homeostasis likely through controlling Imd coalescence.
Topics & Concepts
HomeostasisDrosophila (subgenus)DysbiosisTheaflavinBiologyBlack teaCell biologyPolyphenolGut floraGeneticsBiochemistryFood scienceGeneAntioxidantGenetics, Aging, and Longevity in Model OrganismsInsect Utilization and EffectsInvertebrate Immune Response Mechanisms