Metformin mitigates adipogenesis of fibro-adipogenic progenitors after rotator cuff tears via activating mTOR/ULK1-mediated autophagy
Hao Zhou, Xingzuan Lin, Shujing Feng, Siyuan Zhu, Han Zhou, Huifang Chen, He Youwu, Zekai Wang, Ru Wang, Xiexiang Shao, Jianhua Wang
Abstract
The current study demonstrated that gender-specific disparities in muscular fatty infiltration are attributed to mTOR/ULK1-mediated autophagy of FAPs. Decreased autophagic activity contributes to adipogenic differentiation in female FAPs after RCT. Moreover, metformin could enhance mTOR/ULK1-mediated autophagic processes of FAPs, thereby alleviating fatty infiltration and improving shoulder functionality after RCT. Therefore, metformin could be a promising noninvasive intervention to ameliorate muscular fatty infiltration of RCT.
Topics & Concepts
AutophagyMetforminULK1Infiltration (HVAC)MedicinePI3K/AKT/mTOR pathwayRotator cuffAdiponectinEverolimusInternal medicineEndocrinologyAMPKBiologyKinaseSurgeryInsulin resistanceInsulinCell biologyProtein kinase ASignal transductionBiochemistryApoptosisPhysicsThermodynamicsSpinal Cord Injury ResearchSports injuries and preventionShoulder Injury and Treatment