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Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study

Mohamed‐Elamir F. Hegazy, Ehab S. Taher, Adel Ghiaty, Ashraf H. Bayoumi

2024Bioorganic Chemistry13 citationsDOI

Topics & Concepts

ChemistryDual (grammatical number)QuinolineHybridSafety profileCombinatorial chemistryBiochemistryComputational biologyStereochemistryPharmacologyOrganic chemistryBotanyBiologyAdverse effectArtLiteratureInflammatory mediators and NSAID effectsSynthesis and Biological EvaluationSynthesis and biological activity
Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study | Litcius